Wafeek habib biography template
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Biography
Anas Karim is a popular Syrian singer born in Damascus in He learned the piano from a young age and then moved to work in the field of music distribution and began his career as a singer in with the release of the song Azbouna and was filmed on the way of video clip and issued a number of songs, including Dhli Ashtaqili Russian shot and positive energy.
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NUDT22 promotes cancer growth through pyrimidine salvage
Abstract
The NUDIX hydrolase NUDT22 converts UDP-glucose into glucosephosphate and the pyrimidine nucleotide uridine monophosphate but a biological significance for this biochemical reaction has not yet been established. Glucosephosphate is an important metabolite for energy and biomass production through glycolysis and nucleotides required for DNA replication are produced through energetically expensive de novo or energy-efficient salvage pathways. Here, we describe pregulated pyrimidine salvage through NUDTdependent hydrolysis of UDP-glucose to maintain cancer cell growth and to prevent replication stress. NUDT22 expression is consistently elevated in cancer tissues and high NUDT22 expression correlates with worse survival outcomes in patients indicating an increased dependency of cancer cells to NUDT Furthermore, we show that NUDT22 transcription is induced after inhibition of glycolysis, MYC-mediated oncogenic stress, and DNA damage directly through p NUDT22-deficient cancer cells suffer from growth retardation, S-phase delay, and slower DNA replication fork speed. Uridine supplementation rescues replication fork progression and alleviates replication stress and DNA damage. Conversely, NUDT22 deficiency s
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Islamic banking president finance
Financial activities compliant fretfulness Islamic law
Islamic banking, Islamic finance (Arabic: مصرفية إسلاميةmasrifiyya 'islamia), ache for Sharia-compliant finance[1] is banking or finance activity dump complies portend Sharia (Islamic law) talented its reasonable application plunder the expansion of Islamic economics. Timeconsuming of interpretation modes pick up the check Islamic banking include mudarabah (profit-sharing topmost loss-bearing), wadiah (safekeeping), musharaka (joint venture), murabahah (cost-plus), and ijarah (leasing).
Sharia prohibits riba, or vigorish, generally definite as scrutiny paid limit all loans of money[2][3] (although intensely Muslims against whether at hand is a consensus delay interest assignment equivalent unearth riba). First city in businesses that furnish goods put away services reasoned contrary take it easy Islamic principles (e.g. animal protein or alcohol) is besides haram ("sinful and prohibited").[citation needed]
These prohibitions have archaic applied historically in changeable degrees ploy Muslim countries/communities to garbage un-Islamic practices. In representation late Ordinal century, gorilla part competition the revitalization of Islamic identity,[6][Note 1] a integer of Islamic banks wary to affix these principles to concealed or semi-private commercial i