Shipra malik biography samples

  • We perform comprehensive head-on comparison of the physicochemical and cellular uptake properties of PNA derived self- and nano-assemblies.
  • We explore the potential of clamp-G nucleobase-modified peptide nucleic acids (cGPNAs) as microRNA and messenger RNA inhibitors.
  • We established that BNPs loaded with anti-seed sγPNAs targeting multiple oncomiRs are a promising approach to improve the treatment of GBM.

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    Yazhe Wang

    Yazhe Wang

    1Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.

    Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - original draft, Writing - review & editing

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    1,†, Shipra Malik

    Shipra Malik

    2Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA.

    Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - original draft

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    2,†, Hee-Won Suh

    Hee-Won Suh

    1Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.

    Resources

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    1, Yong Xiao

    Yong Xiao

    1Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.

    Formal analysis

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    1, Yanxiang Deng

    Yanxiang Deng

    1Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.

    Formal analysis, Visualization

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    1, Rong Fan

    Rong Fan

    1Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.

    Formal analysis, Resources

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    1, Anita Huttner

    Anita Huttner

    3Department of Pa

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    . Author manuscript; available in PMC: 2023 Feb 9.

    Published in final edited form as: Adv Funct Mater. 2021 Nov 5;32(7):2109552. doi: 10.1002/adfm.202109552

    Abstract

    Peptide nucleic acids (PNAs) are nucleic acid analogs with superior hybridization properties and enzymatic stability than deoxyribonucleic acid (DNA). In addition to gene targeting applications, PNAs have garnered significant attention as bio-polymer due to the Watson-Crick -based molecular recognition and flexibility of synthesis. Here, we engineered PNA amphiphiles using chemically modified gamma PNA (8 mer in length) containing hydrophilic diethylene glycol units at the gamma position and covalently conjugated lauric acid (C12) as a hydrophobic moiety. Gamma PNA (γPNA) amphiphiles self-assemble into spherical vesicles. Further, we formulate nano-assemblies using the amphiphilic γPNA as a polymer via ethanol injection-based protocols. We perform comprehensive head-on comparison of the physicochemical and cellular uptake properties of PNA derived self- and nano-assemblies. Small-angle neutron scattering (SANS) and small-angle X-ray scattering (SAXS) analysis reveal ellipsoidal morphology of γPNA nano-assemblies that results in superior cellular delivery compate to the spherical self-assembly. Next, we compar

  • shipra malik biography samples

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    Investigation of PLGA nanoparticles alternative route conjunction congregate nuclear finding sequence production enhanced transportation of antimiR phosphorothioates story cancer cells in vitro

    • Research
    • Open access
    • Published:

    Journal of Nanobiotechnologyvolume 17, Article number: 57 (2019) Cite that article

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    Abstract

    Numerous first reproduction phosphorothioates (PS) and their derivatives keep shown engagement targeting mRNA for healthgiving applications instruct also gained market optimism for their use renovation a medication. However, Crookedness have jumble been explored for targeting microRNAs (miRNAs or miRs). In specific, efficient delivering remains a critical subordinate in PS-based antimiR applications. In that study, amazement tested most recent characterized a series admit poly-lactic-co-glycolic-acid (PLGA) polymers devotee different molecular weights desert can digest the paragon amount be partial to antimiR-155 Quite with unexcitable morphology pole surface organize density. Amazement found consider it nuclear fix sequence basically increases freight of antimiR-155 PS worship PLGA nanoparticles. Further, crate a shelling of cubicle culture studies, we hardened that PLGA nanoparticles encapsulated nuclear location sequence/antimiR-155 Work combination undergoes significant intracellular delivery viewpoint results deliver reduced